2021 Publications
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ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma.
Víctor A. Arrieta*, Andrew X. Chen*, J. Robert Kane, Seong Jae Kang, Cynthia Kassab, Crismita Dmello, Junfei Zhao, Kirsten B. Burdett, Pavan S. Upadhyayula, Catalina Lee-Chang, Joseph Shilati, Dinesh Jaishankar, Li Chen, Andrew Gould, Daniel Zhang, Jinzhou Yuan, Wenting Zhao, Xiaoyang Ling, Jared K. Burks, Brice Laffleur, Christina Amidei, Jeffrey N. Bruce, Rimas V. Lukas, Jonathan T. Yamaguchi, David Cieremans, Gerson Rothschild, Uttiya Basu, Matthew McCord, Daniel J. Brat, Hui Zhang, Lee A. D. Cooper, Bin Zhang, Peter Sims, Tim F. Cloughesy, Robert Prins, Peter Canoll, Roger Stupp, Amy B. Heimberger, Craig Horbinski, Fabio M. Iwamoto+, Raul Rabadan+, Adam M. Sonabend+.
*These authors have contributed equally to this work. +Corresponding authors.

Targetable Bone Marrow-Niche Axis for the Treatment of Acute Myeloid Leukemia
Marta Galan-Diez, Florence Borot, Abdullah M. Ali, Junfei Zhao, Eva Gil-Iturbe, Xiaochuan Shan, Xi-Ping Huang, Irwin Kurland, Bryan L. Roth, Matthias Quick, Siddhartha Mukherjee, Raul Rabadan, Martin P. Carroll, Azra Raza, Stavroula Kousteni

HHV-6 in the Lymphoma Microenvironment: Both Chicken and Egg?
Genevieve M Crane, Dmitry Tychinin, Anton Karelin, Aleksandr Cherdintsev, Olga Kudryashova, Evgeniy Egorov, Sandrine Degryse, Nikita Kotlov, Alexander Bagaev, Joseph Casano, Jonathan Reichel, Lisa Giulino Roth, Mikhail Roshal, Sakellarios Zairis, Raul Rabadan, Olivier Elemento, Giorgio Inghirami, Ethel Cesarman

A Phase I Study of the Combination of Pexidartinib and Sirolimus to Target Tumor-Associated Macrophages in Unresectable Sarcoma and Malignant Peripheral Nerve Sheath Tumors.
Gulam A. Manji, Brian A. Van Tine, Shing M. Lee, Alexander G. Raufi, Ilenia Pellicciotta, Angela C. Hirbe, Jaya Pradhan, Andrew Chen, Raul Rabadan, Gary K. Schwartz.

A persistent look at how tumours evade therapy.
Karen Gomez, Raul Rabadan.

Recombination and lineage-specific mutations led to the emergence of SARS-CoV-2.
Juan Ángel Patiño-Galindo, Ioan Filip, Ratul Chowdhury, Costas D. Maranas, Peter K. Sorger, Mohammed AlQuraishi, Raul Rabadan+.
*These authors have contributed equally to this work. +Corresponding authors.

Transcriptional control of CBX5 by the RNA-binding proteins RBMX and RBMXL1 maintains chromatin state in myeloid leukemia
Camila Prieto, Diu T. T. Nguyen, Zhaoqi Liu, Justin Wheat, Alexendar Perez, Saroj Gourkanti, Timothy Chou, Ersilia Barin, Anthony Velleca, Thomas Rohwetter, Arthur Chow, James Taggart, Angela M. Savino, Katerina Hoskova, Meera Dhodapkar, Alexandra Schurer, Trevor S. Barlowe, Ly P. Vu, Christina Leslie, Ulrich Steidl, Raul Rabadan, Michael G. Kharas.

The Holdout Randomization Test: Principled and Easy Black Box Feature Selection.
W Tansey, V Veitch, H Zhang, R Rabadan, DM Blei.

iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4
Delin Chen, Bo Chu, Xin Yang, Zhaoqi Liu, Ying Jin, Ning Kon, Raul Rabadan, Xuejun Jiang, Brent R. Stockwell, Wei Gu.

Genetic mechanisms of HLA-I loss and immune escape in diffuse large B cell lymphoma
Marco Fangazio, Erik Ladewig, Karen Gomez, Laura Garcia-Ibanez, Rahul Kumar, Julie Teruya-Feldstein, Davide Rossi, Ioan Filip, Qiang Pan-Hammarström, Giorgio Inghirami, Renzo Boldorini, German Ott, Annette M. Staiger, Björn Chapuy, Gianluca Gaidano, Govind Bhagat, Katia Basso, Raul Rabadan, Laura Pasqualucci, Riccardo Dalla-Favera.

Single-cell characterization of macrophages in glioblastoma reveals MARCO as a mesenchymal pro-tumor marker
Andrew X. Chen, Robyn D. Gartrell, Junfei Zhao, Pavan S. Upadhyayula, Wenting Zhao, Jinzhou Yuan, Hanna E. Minns, Athanassios Dovas, Jeffrey N. Bruce, Anna Lasorella, Antonio Iavarone, Peter Canoll, Peter A. Sims, Raul Rabadan.

Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations
Silvia Affo, Ajay Nair, Francesco Brundu, Aashreya Ravichandra, Sonakshi Bhattacharjee, Michitaka Matsuda, LiKang Chin, Aveline Filliol, Wen Wen, Xinhua Song, Aubrianna Decker, Jeremy Worley, Jorge Matias Caviglia, Lexing Yu, Deqi Yin, Yoshinobu Saito, Thomas Savage, Rebecca G. Wells, Matthias Mack, Lars Zender, Nicholas Arpaia, Helen E. Remotti, Raul Rabadan, Peter Sims, Anne-Laure Leblond, Achim Weber, Marc-Oliver Riener, Brent R. Stockwell, Jellert Gaublomme, Josep M. Llovet, Raghu Kalluri, George K. Michalopoulos, Ekihiro Seki, Daniela Sia, Xin Chen, Andrea Califano, Robert F. Schwabe.

Pregnancy Specific Glycoproteins: A Possible Mediator of Immune Tolerance of Cancers
Junfei Zhao, Raul Rabadan, Arnold J. Levine.

PDK1 is Required for Maintenance of CD4+ Foxp3+ Regulatory T Cell Function
Hyunju Oh, Jingyao Zhao, Yenkel Grinberg-Bleyer, Thomas S. Postler, Pingzhang Wang, Sung-Gyoo Park, Raul Rabadan, Matthew S. Hayden, Sankar Ghosh.

Functional Interrogation Of DNA Damage Response Variants With Base Editing Screens
Raquel Cuella-Martin, Samuel B.Hayward, Xiao Fan, Xiao Chen, Jen-Wei Huang, Angelo Taglialatela, Giuseppe Leuzzi, Junfei Zhao, Raul Rabadan, Chao Lu, Yufeng Shen, Alberto Ciccia.

Global Patterns Of Recombination Across Human Viruses
Juan Ángel Patiño-Galindo, Ioan Filip, Raul Rabadan.

Comprehensive Characterization Of Protein-Protein Interactions Perturbed By Disease Mutations
Feixiong Cheng, Junfei Zhao, Yang Wang, Weiqiang Lu, Zehui Liu, Yadi Zhou, William R. Martin, Ruisheng Wang, Jin Huang, Tong Hao, Hong Yue, Jing Ma, Yuan Hou, Jessica A. Castrillon, Jiansong Fang, Justin D. Lathia, Ruth A. Keri, Felice C. Lightstone, Elliott Marshall Antman, Raul Rabadan, David E. Hill, Charis Eng, Marc Vidal, Joseph Loscalzo.

Computing The Role Of Alternative Splicing In Cancer
Zhaoqi Liu, Raul Rabadan.

FYN-TRAF3IP2 Induces NF-κB Signaling-Driven Peripheral T-cell Lymphoma
Christine S. Moon, Clara Reglero, Jose R. Cortes, S. Aidan Quinn, Silvia Alvarez, Junfei Zhao, Wen-Hsuan W. Lin, Anisha J. Cooke, Francesco Abate, Craig R. Soderquist, Claudia Fiñana, Giorgio Inghirami, Elias Campo, Govind Bhagat, Raul Rabadan, Teresa Palomero, Adolfo A. Ferrando.

The UVSSA Complex Alleviates MYC-driven Transcription Stress
Mai Sato, Andrew Walter Liebau, Zhaoqi Liu, Lizhi Liu, Raul Rabadan, Jean Gautier.