A Structure-Informed Atlas of Human-Virus Interactions.
Gorka Lasso, Sandra V. Mayer, Evandro R. Winkelmann, Tim Chu, Oliver Elliott, Juan Angel Patino-Galindo, Kernyu Park, Raul Rabadan, Barry Honig, Sagi D. Shapira.
Tissue-Resident Memory T Cells Mediate Immune Homeostasis in the Human Pancreas Through the PD-1/PD-L1 Pathway.
Stuart Weisberg, Dustin J Carpenter, Michael Chait, Pranay Dogra, Robyn D Gartrell-Corrado, Andrew X Chen, Sean Campbell, Wei` Liu, Pooja Saraf, Mark E Snyder, Masaru Kubota, Nichole M Danzl, Beth A Schrope, Raul Rabadan, Yvonne Saenger, Xiaojuan Chen, Donna Farberi.
Somatic mutations and cell identity linked by Genotyping of Transcriptomes.
Nam AS, Kim KT, Chaligne R, Izzo F, Ang C, Taylor J, Myers RM, Abu-Zeinah G, Brand R, Omans ND, Alonso A, Sheridan C, Mariani M, Dai X, Harrington E, Pastore A, Cubillos-Ruiz JR, Tam W, Hoffman R, Rabadan R, Scandura JM, Abdel-Wahab O, Smibert P, Landau DA.
TOP2B Enzymatic Activity on Promoters and Introns Modulates Multiple Oncogenes in Human Gliomas.
Edgar Gonzalez-Buendia, Junfei Zhao, Lu Wang, Subhas Mukherjee, Stacy A Marshall, Eric Feldstein, Daniel Zhang, Catalina Lee-Chang, Aayushi Mahajan, Li Chen, Ronald Realubit, Charles Karan, Lisa Magnuson, Craig Horbinski, Jann N Sarkaria, Ahmed Mohyeldin, Ichiro Nakano, Charles D James, Daniel J Brat, Atique Ahmed, Peter Canoll, Raul Rabadan, Ali Shilatifard, Adam M Sonabend.
High density of CD68+ HLA-DR-macrophages in the stroma of primary melanoma correlates with an unfavorable immune microenvironment as assessed by Digital Spatial Profiling.
Emanuelle M Rizk, Andrew Chen, Andrew M Silverman, Douglas K Marks, Raul Rabadan, Kit Fuhrman, Alison VanSchoiack, Yan Liang, Joseph Beechem, Yvonne M Saenger, Robyn D Gartrell.
Double PIK3CA mutations in cis enhance oncogene activation and sensitivity to PI3K alpha inhibitors in breast cancer.
Neil Vasan, Pedram Razavi, Jared Johnson, Hong Shao, Hardik Shah, Alesia Antoine, Erik Ladewig, Alexander Gorelick, Eneda Toska, Guotai Xu, Abiha Kazmi, Matthew T Chang, Barry S Taylor, Maura N Dickler, Komal Jhaveri, Raul Rabadan, Ed Reznik, Melissa L Smith, Robert Sebra, Lewis C Cantley, Maurizio Scaltriti, Jose Baselga.
Novel insights into the genetics and epigenetics of MALT lymphoma unveiled by next generation sequencing analyses.
Cascione L, Rinaldi A, Bruscaggin A, Tarantelli C, Arribas AJ, Kwee I, Pecciarini L, Mensah AA, Spina V, Chung EYL, Terzi di Bergamo L, Dirnhofer S, Tzankov A, Miranda RN, Young KH, Traverse-Glehen A, Gaidano G, Swerdlow SH, Gascoyne R, Rabadan R, Ponzoni M, Bhagat G, Rossi D, Zucca E, Bertoni F.
Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas upon Combined Inhibition of EGFR and C-RAF.
Blasco MT, Navas C, Martín-Serrano G, Graña-Castro O, Lechuga CG, Martín-Díaz L, Djurec M, Li J, Morales-Cacho L, Esteban-Burgos L, Perales-Patón J, Bousquet-Mur E, Castellano E, Jacob HKC, Cabras L, Musteanu M, Drosten M, Ortega S, Mulero F, Sainz B Jr, Dusetti N, Iovanna J, Sánchez-Bueno F, Hidalgo M, Khiabanian H, Rabadán R, Al-Shahrour F, Guerra C, Barbacid M.
Rates of asymptomatic respiratory virus infection across age groups.
Galanti M, Birger R, Ud-Dean M, Filip I, Morita H, Comito D, Anthony S, Freyer GA, Ibrahim S, Lane B, Matienzo N, Ligon C, Rabadan R, Shittu A, Tagne E, Shaman J.
Hypermutagenesis in untreated adult gliomas due to inherited mismatch mutations.
Jason K Sa, Seung Won Choi, Junfei Zhao, Yeri Lee, Jing Zhang, Doo‐Sik Kong, Jung Won Choi, Ho Jun Seol, Jung‐Il Lee, Antonio Iavarone, Raul Rabadan, Do‐Hyun Nam.
A pan-cancer analysis of driver gene mutations, DNA methylation and gene expressions reveals that chromatin remodeling is a major mechanism inducing global changes in cancer epigenomes.
Ahrim Youn, Kyung In Kim, Raul Rabadan, Benjamin Tycko, Yufeng Shen, Shuang Wang
Suppression of GATA3 Binding Drives Selective Abrogation of NOTCH1-MYC Enhancer Activity By Nucleosome Invasion in Thymocyte Development and Leukemia.
Laura Belver, Alexander Y Yang, Daniel Herranz, Aidan Quinn, Francesco G Brundu, Pablo Perez-Duran, Silvia Alvarez, Devya Gurung, Pedro P Rocha, Ramya Raviram, Marissa Rashkovan, Raul Rabadan, Adolfo A Ferrando
High Throughput Droplet Single-Cell Genotyping of Transcriptomes (GoT) Reveals the Cell Identity Dependency of the Transcriptional Output of Somatic Mutations.
Anna S Nam, Kyu-Tae Kim, Ronan Chaligne, Franco Izzo, Chelston Ang, Nathaniel Omans, Alessandro Pastore, Justin Taylor, Alicia Alonso, Wayne Tam, Ronald Hoffman, Joseph Scandura, Raul Rabadan, Omar I Abdel-Wahab, Peter Smibert, Dan A Landau.
Mutations in the RNA Splicing Factor SF3B1 Promote Transformation through MYC Stabilization.
Akihide Yoshimi, Zhaoqi Liu, Wang Jiguang, Hana Cho, Stanley C Lee, Michelle Ki, Lillian E Bitner, Timothy Chu, Anthony R Mato, Peter P Ruvolo, Giulia Fabbri, Laura Pasqualucci, Raul Rabadan, Omar I Abdel-Wahab
DDIS-13. UNDERSTANDING GLIOBLASTOMA SUSCEPTIBILITY TO TOP2-TARGETING DRUGS FOR PERSONALIZED THERAPY.
Chidiebere Awah, Edgar Gonzalez-Buendía, Junfei Zhao, Eric Feldstein, Li Chen, Aayushi Mahajan, Louisa Warnke, Lu Wang, Cheol Park, Jan Winter, Silvana Konermann, Ali Shilatifard, C David James, Raul Rabadan, Patrick Hsu, Mukesh Bansal, Atique Ahmed, Adam Sonabend
Pharmacogenomic landscape of patient-derived tumor cells informs precision oncology therapy.
Jin-Ku Lee, Zhaoqi Liu, Jason K. Sa, Sang Shin, Jiguang Wang, Mykola Bordyuh, Hee Jin Cho, Oliver Elliott, Timothy Chu, Seung Won Choi, Daniel I. S. Rosenbloom, In-Hee Lee, Yong Jae Shin, Hyun Ju Kang, Donggeon Kim, Sun Young Kim, Moon-Hee Sim, Jusun Kim, Taehyang Lee, Yun Jee Seo, Hyemi Shin, Mijeong Lee, Sung Heon Kim, Yong-Jun Kwon, Jeong-Woo Oh, Minsuk Song, Misuk Kim, Doo-Sik Kong, Jung Won Choi, Ho Jun Seol, Jung-Il Lee, Seung Tae Kim, Joon Oh Park, Kyoung-Mee Kim, Sang-Yong Song, Jeong-Won Lee, Hee-Cheol Kim, Jeong Eon Lee, Min Gew Choi, Sung Wook Seo, Young Mog Shim, Jae Ill Zo, Byong Chang Jeong, Yeup Yoon, Gyu Ha Ryu, Nayoung K. D. Kim, Joon Seol Bae, Woong-Yang Park, Jeongwu Lee, Roel G. W. Verhaak, Antonio Iavarone, Jeeyun Lee, Raul Rabadan, Do-Hyun Nam.
Distinct genomic profile and specific targeted drug responses in adult cerebellar glioblastoma.
Hee Jin Cho, Junfei Zhao, Sang Won Jung, Erik Ladewig, Doo-Sik Kong, Yeon-Lim Suh, Yeri Lee, Donggeon Kim, Sun Hee Ahn, Mykola Bordyuh, Hyun Ju Kang, Jason K Sa, Yun Jee Seo, Sung Tae Kim, Do Hoon Lim, Yun-Sik Dho, Jung-Il Lee, Ho Jun Seol, Jung Won Choi, Woong-Yang Park, Chul-Kee Park, Raul Rabadan, Do-Hyun Nam.
Quantitative compositional and spatial analysis of tumor microenvironment (TME) in primary melanoma.
Robyn D Gartrell, Andrew Chen, Douglas K Marks, Thomas D Hart, Gen Li, Alan Wu, Yan Lu, Camden Esancy, Zoe Blake, Bret Taback, Raul Rabadan, Howard L Kaufman, Charles G Drake, Basil Horst, Anthea Monod, Yvonne Saenger.
Correlation of immune infiltration of cytotoxic T cells and activated microglia in glioblastoma (GBM) post anti-PD1 therapy with response.
Andrew Silverman, Robyn Denise Gartrell, Junfei Zhao, Syeda Sabeeka Batool, Thomas D Hart, Syed Shabee Hasan, James H Garvin, George Zanazzi, Fabio Massaiti Iwamoto, Raul Rabadan, Peter Canoll, Yvonne M Saenger.
The Egyptian rousette genome reveals unexpected features of bat antiviral immunity.
Stephanie S Pavlovich, Sean P Lovett, Galina Koroleva, Jonathan C Guito, Catherine E Arnold, Elyse R Nagle, Kirsten Kulcsar, Albert Lee, Françoise Thibaud-Nissen, Adam J Hume, Elke Mühlberger, Luke S Uebelhoer, Jonathan S Towner, Raul Rabadan, Mariano Sanchez-Lockhart, Thomas B Kepler, Gustavo Palacios.
Increased HOXA5 expression provides a selective advantage for gain of whole chromosome 7 in IDH wild-type glioblastoma.
Patrick J Cimino, Youngmi Kim, Hua-Jun Wu, Jes Alexander, Hans-Georg Wirsching, Frank Szulzewsky, Ken Pitter, Tatsuya Ozawa, Jiguang Wang, Julio Vazquez, Sonali Arora, Raul Rabadan, Ross Levine, Franziska Michor, Eric C Holland.
Quantitative Analysis of Immune Infiltrates in Primary Melanoma.
Robyn D Gartrell, Douglas K Marks, Thomas D Hart, Gen Li, Danielle R Davari, Alan Wu, Zoë Blake, Yan Lu, Kayleigh N Askin, Anthea Monod, Camden L Esancy, Edward C Stack, Dan Tong Jia, Paul M Armenta, Yichun Fu, Daisuke Izaki, Bret Taback, Raul Rabadan, Howard L Kaufman, Charles G Drake, Basil A Horst, Yvonne M Saenger.
Comprehensive characterisation of compartment-specific long non-coding RNAs associated with pancreatic ductal adenocarcinoma.
Luis Arnes, Zhaoqi Liu, Jiguang Wang, Hans Carlo Maurer, Irina Sagalovskiy, Marta Sanchez-Martin, Nikhil Bommakanti, Diana C Garofalo, Dina A Balderes, Lori Sussel, Kenneth P Olive, Raul Rabadan.
Genetic landscape of ultra-stable chronic lymphocytic leukemia patients.
S Raponi, I Del Giudice, M Marinelli, J Wang, L Cafforio, C Ilari, A Piciocchi, M Messina, S Bonina, S Tavolaro, M Bordyuh, P Mariglia, N Peragine, FR Mauro, S Chiaretti, S Molica, M Gentile, A Visentin, L Trentin, GM Rigolin, A Cuneo, F Diop, D Rossi, G Gaidano, A Guarini, R Rabadan, R Foà.
Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors.
Magdolna Djurec, Osvaldo Graña, Albert Lee, Kevin Troulé, Elisa Espinet, Lavinia Cabras, Carolina Navas, María Teresa Blasco, Laura Martín-Díaz, Miranda Burdiel, Jing Li, Zhaoqi Liu, Mireia Vallespinós, Francisco Sanchez-Bueno, Martin R Sprick, Andreas Trumpp, Bruno Sainz, Fátima Al-Shahrour, Raul Rabadan, Carmen Guerra, Mariano Barbacid.
Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia.
Gannie Tzoneva, Chelsea L Dieck, Koichi Oshima, Alberto Ambesi-Impiombato, Marta Sánchez-Martín, Chioma J Madubata, Hossein Khiabanian, Jiangyan Yu, Esme Waanders, Ilaria Iacobucci, Maria Luisa Sulis, Motohiro Kato, Katsuyoshi Koh, Maddalena Paganin, Giuseppe Basso, Julie M Gastier-Foster, Mignon L Loh, Renate Kirschner-Schwabe, Charles G Mullighan, Raul Rabadan, Adolfo A Ferrando.
Somatic CLL mutations occur at multiple distinct hematopoietic maturation stages: documentation and cautionary note regarding cell fraction purity.
S Marsilio, H Khiabanian, G Fabbri, S Vergani, C Scuoppo, E Montserrat, EJ Shpall, M Hadigol, P Marin, KR Rai, R Rabadan, S Devereux, L Pasqualucci, N Chiorazzi.
Refined karyotype-based prognostic stratification of chronic lymphocytic leukemia with a low-and very-low-risk genetic profile.
ID Giudice, GM Rigolin, S Raponi, L Cafforio, C Ilari, J Wang, M Bordyuh, A Piciocchi, M Marinelli, M Nanni, S Tavolaro, M Filetti, A Bardi, E Tammiso, E Volta, M Negrini, E Saccenti, FR Mauro, D Rossi, G Gaidano, A Guarini, R Rabadan, A Cuneo, R Foà.
The B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3β inhibition.
Varano G, Raffel S, Sormani M, Zanardi F, Lonardi S, Zasada C, Perucho L, Petrocelli V, Haake A, Lee AK, Bugatti M, Paul U, Van Anken E, Pasqualucci L, Rabadan R, Siebert R, Kempa S, Ponzoni M, Facchetti F, Rajewsky K, Casola S.
Nuclear Proximity of Mtr4 to RNA Exosome Restricts DNA Mutational Asymmetry.
Lim J, Giri PK, Kazadi D, Laffleur B, Zhang W, Grinstein V, Pefanis E, Brown LM, Ladewig E, Martin O, Chen Y, Rabadan R, Boyer F, Rothschild G, Cogné M, Pinaud E, Deng H, Basu U.
Spatiotemporal genomic architecture informs precision oncology in glioblastoma.
Lee JK*, Wang J*, Sa JK*, Ladewig E*, Lee HO, Lee IH, Kang HJ, Rosenbloom DS, Camara PG, Liu Z, van Nieuwenhuizen P, Jung SW, Choi SW, Kim J, Chen A, Kim KT, Shin S, Seo YJ, Oh JM, Shin YJ, Park CK, Kong DS, Seol HJ, Blumberg A, Lee JI, Iavarone A, Park WY+, Rabadan R+, Nam DH+.
* These authors have contributed equally to this work. +Corresponding authors.
Activating mutations and translocations in the guanine exchange factor VAV1 in peripheral T-cell lymphomas.
Francesco Abate, Ana C. da Silva-Almeida, Sakellarios Zairis, Javier Robles-Valero, Lucile Couronne, Hossein Khiabanian, S. Aidan Quinn, Mi-Yeon Kim, Maria Antonella Laginestra, Christine Kim, Danilo Fiore, Govind Bhagat, Miguel Angel Piris, Elias Campo, Izidore S. Lossos, Olivier A. Bernard, Giorgio Inghirami, Stefano Pileri, Xosé R. Busteo, Raul Rabadan, Adolfo A. Ferrando, and Teresa Palomero.
Mutational landscape, clonal evolution patterns, and role of RAS mutations in relapsed acute lymphoblastic leukemia.
Koichi Oshima*, Hossein Khiabanian*, Ana C. da Silva-Almeida, Gannie Tzoneva, Francesco Abate, Alberto Ambesi-Impiombato, Marta Sanchez-Martin, Zachary Carpenter, Alex Penson, Arianne Perez-Garcia, Cornelia Eckert, Concepción Nicolas, Milagros Balbin, Maria Luisa Sulis, Motohiro Kato, Katsuyoshi Koh, Maddalena Paganin, Giuseppe Basso, Julie M. Gastier-Foster, Meenakshi Devidas, Mignon L. Loh, Renate Kirschner-Schwabe, Teresa Palomero+, Raul Rabadan+, and Adolfo A. Ferrando+.
Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors.
Kenta Yamamoto, Jiguang Wang, Lisa Sprinzen, Jun Xu, Christopher J Haddock, Chen Li, Brian J Lee, Denis G Loredan, Wenxia Jiang, Alessandro Vindigni, Dong Wang, Raul Rabadan, and Shan Zha.
Jiguang Wang, Emanuela Cazzato, Erik Ladewig, Veronique Frattini, Daniel I S Rosenbloom, Sakellarios Zairis, Francesco Abate, Zhaoqi Liu, Oliver Elliott, Yong-Jae Shin, Jin-Ku Lee, In-Hee Lee, Woong-Yang Park, Marica Eoli, Andrew J Blumberg, Anna Lasorella, Do-Hyun Nam, Gaetano Finocchiaro, Antonio Iavarone, Raul Rabadan.
A Case of T-cell Acute Lymphoblastic Leukemia Relapsed As Myeloid Acute Leukemia.
Paganin M, Buldini B, Germano G, Seganfreddo E, Meglio AD, Magrin E, Grillo F, Pigazzi M, Rizzari C, Cazzaniga G, Khiabanian H, Palomero T, Rabadan R, Ferrando AA, Basso G.
Prognostic and therapeutic role of targetable lesions in B-lineage acute lymphoblastic leukemia without recurrent fusion genes.
Messina M, Chiaretti S, Wang J, Fedullo AL, Peragine N, Gianfelici V, Piciocchi A, Brugnoletti F, Di Giacomo F, Pauselli S, Holmes AB, Puzzolo MC, Ceglie G, Apicella V, Mancini M, Te Kronnie G, Testi AM, Vitale A, Vignetti M, Guarini A, Rabadan R, Foà R.
Clonality Analysis of Immunoglobulin Gene Rearrangement by Next-Generation Sequencing in Endemic Burkitt Lymphoma Suggests Antigen Drive Activation of BCR as Opposed to Sporadic Burkitt Lymphoma.
Teresa Amato, Francesco Abate, Pierpaolo Piccaluga, Michele Iacono, Chiara Fallerini, Alessandra Renieri, Giulia De Falco, Maria Raffaella Ambrosio, Vaselious Mourmouras, Martin Ogwang, Valeria Calbi, Raul Rabadan, Michael Hummel, Stefano Pileri, Lorenzo Leoncini, Cristiana Bellan.
Inter- and intra-patient clonal and subclonal heterogeneity of chronic lymphocytic leukaemia: evidences from circulating and lymph nodal compartments.
Del Giudice I, Marinelli M, Wang J, Bonina S, Messina M, Chiaretti S, Ilari C, Cafforio L, Raponi S, Mauro FR, Di Maio V, De Propris MS, Nanni M, Ciardullo C, Rossi D, Gaidano G, Guarini A, Rabadan R, Foà R.
The mutational landscape of CTCL and Sézary syndrome.
Ana Carolina da Silva Almeida*, Francesco Abate*, Hossein Khiabanian, Estela Martinez-Escala, Joan Guitart, Cornelis P. Tensen, Maarten H. Vermeer, Raul Rabadan+, Adolfo Ferrando+ and Teresa Palomero+.
Identification of a new subclass of ALK negative ALCL expressing aberrant levels of ERBB4 transcripts.
Scarfò I, Pellegrino E, Mereu E, Kwee I, Agnelli L, Bergaggio E, Garaffo G, Vitale N, Caputo M, Machiorlatti R, Circosta P, Abate F, Barreca A, Novero D, Mathew S, Rinaldi A, Tiacci E, Serra S, Deaglio S, Neri A, Falini B, Rabadan R, Bertoni F, Inghirami G, Piva R.
RNA Exosome-Regulated Long Non-Coding RNA Transcription Controls Super-Enhancer Activity.
Evangelos Pefanis*, Jiguang Wang*, Gerson Rothschild*, Junghyun Lim*, David Kazadi, Jianbo Sun, Alexander Federation, Jaime Chao, Oliver Elliott, Zhi-Ping Liu, Aris N. Economides, James E. Bradner, Raul Rabadan+, Uttiya Basu+.
Convergent Mutations and Kinase Fusions Lead to Oncogenic STAT3 Activation in Anaplastic Large Cell Lymphoma.
Ramona Crescenzo*, Francesco Abate*, Elena Lasorsa*, Fabrizio Tabbo, Marcello Gaudiano, Nicoletta Chiesa, Filomena Di Giacomo, Elisa Spaccarotella, Luigi Barbarossa, Elisabetta Ercole, Maria Todaro, Michela Boi, Andrea Acquaviva, Elisa Ficarra, Domenico Novero, Andrea Rinaldi, Thomas Tousseyn, Andreas Rosenwald, Lukas Kenner, Lorenzo Cerroni, Alexander Tzankov, Maurilio Ponzoni, Marco Paulli, Dennis Weisenburger, Wing C. Chan, Javeed Iqbal, Miguel A. Piris, Alberto Zamo, Carmela Ciardullo, Davide Rossi, Gianluca Gaidano, Stefano Pileri, Enrico Tiacci, Brunangelo Falini, Leonard D. Shultz, Laurence Mevellec, Jorge E. Vialard, Roberto Piva, Francesco Bertoni, Raul Rabadan‡, Giorgio Inghirami‡.
A Targetable GATA2-IGF2 Axis Confers Aggressiveness in Lethal Prostate Cancer.
Samuel J. Vidal, Veronica Rodriguez-Bravo, S. Aidan Quinn, Ruth Rodriguez-Barrueco, Amaia Lujambio, Estrelania Williams, Xiaochen Sun, Janis de la Iglesia-Vicente, Albert Lee, Ben Readhead, Xintong Chen, Matthew Galsky, Berta Esteve, Daniel P. Petrylak, Joel T. Dudley, Raul Rabadan, Jose M. Silva, Yujin Hoshida, Scott W. Lowe, Carlos Cordon-Cardo, Josep Domingo-Domenech.
A novel patient derived tumorgraft model with TRAF1-ALK anaplastic large cell lymphoma translocation.
F Abate, M Todaro, J-A van der Krogt, M Boi, I Landra, R Machiorlatti, F Tabbo, K Messana, A Barreca, D Novero, M Gaudiano, S Aliberti, F Di Giacomo, T Tousseyn, E Lasorsa, R Crescenzo, L Bessone, E Ficarra, A Acquaviva, A Rinaldi, M Ponzoni, D L Longo, S Aime, M Cheng, B Ruggeri, P P Piccaluga, S Pileri, E Tiacci, B Falini, B Pera-Gresely, L Cerchietti, J Iqbal, W C Chan, L D Shultz, I Kwee, R Piva, I Wlodarska, R Rabadan, F Bertoni and G Inghirami the European T-cell Lymphoma Study Group.
Tumor evolutionary directed graphs and the history of chronic lymphocytic leukemia.
Jiguang Wang*, Hossein Khiabanian*, Davide Rossi*, Giulia Fabbri, Valter Gattei, Francesco Forconi, Luca Laurenti, Roberto Marasca, Giovanni Del Poeta, Robin Foà, Laura Pasqualucci, Gianluca Gaidano, Raul Rabadan.
* These authors have contributed equally to this work.
Viral diversity and clonal evolution from unphased genomic data.
Hossein Khiabanian, Zachary Carpenter, Jeffrey Kugelman, Joseph Chan, Vladimir Trifonov, Elyse Nagle, Travis Warren, Patrick Iversen, Sina Bavari, Gustavo Palacios and Raul Rabadan.
* These authors have contributed equally to this work.
Pegasus: a comprehensive annotation and prediction tool for detection of driver gene fusions in cancer.
Francesco Abate*, Sakellarios Zairis*, Elisa Ficarra, Andrea Acquaviva, Chris H Wiggins, Veronique Frattini, Anna Lasorella, Antonio Iavarone, Giorgio Inghirami and Raul Rabadan.
Genetic lesions associated with chronic lymphocytic leukemia chemo-refractoriness.
Monica Messina, Ilaria Del Giudice, Hossein Khiabanian, Davide Rossi, Sabina Chiaretti, Silvia Rasi, Valeria Spina, Antony B. Holmes, Marilisa Marinelli, Giulia Fabbri, Alfonso Piciocchi, Francesca R. Mauro, Anna Guarini, Gianluca Gaidano, Riccardo Dalla-Favera, Laura Pasqualucci, Raul Rabadan, and Robin Foà.
* These authors have contributed equally to this work.
Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts.
Aruna Kode, John S. Manavalan, Ioanna Mosialou, Govind Bhagat, Chozha V. Rathinam, Na Luo, Hossein Khiabanian, Albert Lee, Vundavalli V. Murty, Richard Friedman, Andrea Brum, David Park, Naomi Galili, Siddhartha Mukherjee, Julie Teruya-Feldstein, Azra Raza, Raul Rabadan, Ellin Berman, Stavroula Kousteni.
Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas.
Palomero T*, Couronné L*, Khiabanian H*, Kim MY, Ambesi-Impiombato A, Perez-Garcia A, Carpenter Z, Abate F, Allegretta M, Haydu JE, Jiang X, Lossos IS, Nicolas C, Balbin M, Bastard C, Bhagat G, Piris MA, Campo E, Bernard OA, Rabadan R‡, Ferrando AA‡.
Genetic lesions associated with chronic lymphocytic leukemia transformation to Richter syndrome.
Giulia Fabbri*, Hossein Khiabanian*, Antony B. Holmes, Jiguang Wang, Monica Messina, Charles G. Mullighan, Laura Pasqualucci, Raul Rabadan‡, and Riccardo Dalla-Favera‡.
GAB2 induces tumor angiogenesis in NRAS-driven melanoma.
Yang Y, Wu J, Demir A, Castillo-Martin M, Melamed RD, Zhang G, Fukunaga-Kanabis M, Perez-Lorenzo R, Zheng B, Silvers DN, Brunner G, Wang S, Rabadan R, Cordon-Cardo C, Celebi JT.
* These authors have contributed equally to this work. ‡ These authors have contributed equally to this work.
Transforming Fusions of FGFR and TACC Genes in Human Glioblastoma.
Devendra Singh*, Joseph Minhow Chan*, Pietro Zoppoli*, Francesco Niola*, Ryan Sullivan, Angelica Castano, Eric Minwei Liu, Jonathan Reichel, Paola Porrati, Serena Pellegatta, Kunlong Qiu, Zhibo Gao, Michele Ceccarelli, Riccardo Riccardi, Daniel J. Brat, Abhijit Guha, Ken Aldape, John G. Golfinos, David Zagzag, Tom Mikkelsen, Gaetano Finocchiaro, Anna Lasorella‡, Raul Rabadan‡, Antonio Iavarone‡.
* These authors have contributed equally to this work. ‡ These authors have contributed equally to this work.
Emergence of Fatal Avian Influenza in New England Harbor Seals.
S. J. Anthony*, J. A. St. Leger, K. Pugliares, H. S. Ip, J. M. Chan, Z. W. Carpenter, I. Navarrete-Macias, M. Sanchez-Leon, J. T. Saliki, J. Pedersen, W. Karesh, P. Daszak, R. Rabadan*, T. Rowles, and W. I. Lipkin*.
Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4.
Dapito D H, Mencin A, Gwak G Y, Pradere J P, Jang M K, Mederacke I, Caviglia J M, Khiabanian H, Adeyemi A, Bataller R, Lefkowitch J H, Bower M, Friedman R, Sartor R B, Rabadan R, Schwabe R F.
Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia.
Ntziachristos P, Tsirigos A, Van Vlierberghe P, Nedjic J, Trimarchi T, Sol Flaherty M, Ferres-Marco D, da Ros V, Tang Z, Siegle J, Asp P, Hadler M, Rigo I, De Keersmaecker K, Patel J, Huynh T, Utro F, Poglio S, Samon J B, Paietta E, Racevskis J, Rowe J, Rabadan R, Levine R L, Brown S, Pflumio F, Dominguez M, Ferrando A, Aifantis I.
Analysis of the coding genome of diffuse large B-cell lymphoma.
Pasqualucci L, Trifonov V, Fabbri G, Ma J, Rossi D, Chiarenza A, Wells VA, Grunn A, Messina M, Elliott O, Chan J, Bhagat G, Chadburn A, Gaidano G, Mullighan CG, Rabadan R, Dalla-Favera R.
Genome-Wide Analysis Reveals Frequent Inactivating Mutations of Acetyltransferase Genes In B-Cell Lymphoma.
Pasqualucci L, Dominguez-Sola D, Chiarenza A, Fabbri G, Grunn A, Trifonov V, Kasper L H, Lerach S, Jing M, Rossi D, Mullighan C, Gaidano G, Rabadan R, Brindle P K, and Dalla-Favera R.
Blood (ASH Annual Meeting Abstracts) Nov 2010;116:474.
The Genome of Chronic Lymphocytic Leukemia.
Fabbri G, Trifonov V, Rossi D, Elliott O, Chan J M, Rinaldi A, Kwee I, Bertoni F, Gaidano G, Pasqualucci L, Rabadan R, and Dalla-Favera R.
Blood (ASH Annual Meeting Abstracts) Nov 2010;116:51.
Young and Early Career Investigators: Report from a Global HIV Vaccine Enterprise Working Group.
Dan H Barouch, Thumbi Ndung’u, Galit Alter, Timothy Cardozo, Bhavna Chohan, Jacques Fellay, Nicole Frahm, Jonathan Fuchs, Al Leslie, Yong Liu, Penny Moore, Raul Rabadan.
Heart and skeletal muscle inflammation of farmed salmon is associated with infection with a novel reovirus.
Gustavo Palacios, Marie Lovoll, Torstein Tengs, Mady Hornig, Stephen Hutchison, Jeffrey Hui, Ruth-Torill Kongtorp, Nazir Savji, Ana Bussetti, Alexander Solovyov, Anja Kristoffersen, Christopher Celone, Craig Street, Vladimir Trifonov, David Hirshberg, Raul Rabadan, Michael Egholm, Espen Rimstad, W. Ian Lipkin.
PHF6 mutations in T-cell acute lymphoblastic leukemia.
Van Vlierberghe P, Palomero T, Khiabanian H, Van der Meulen J, Castillo M, Van Roy N, De Moerloose B, Philippé J, González-García S, Toribio M, Taghon T, Zuurbier L, Cauwelier B, Harrison C, Schwab C, Pisecker M, Strehl S, Langerak A, Gecz J, Sonneveld E, Pieters R, Paietta E, Rowe J, Wiernik P, Benoit Y, Soulier J, Poppe B, Yao X, Cordon-Cardo C, Meijerink J, Rabadan R, Speleman F, Ferrando A.
Molecular characterization of severe and mild cases of influenza A (H1N1) 2009 strain from Argentina.
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